• What is monoclonal gammopathy?

    Asked by MyelomaBeacon on Friday, April 5, 2013

    What is monoclonal gammopathy?

    There are just so many terms and options it's hard to get them straight.

    2 Answers from the Community

    • carm's Avatar

      Myeloma Beacon,
      Great question. Lets see if I can explain this to you. It goes by a few names other than monoclonal gammopathy. When something is deemed monoclonal, it means it gets its origin asexually from a single individual or cell. Monoclonal gammopathy is also known as MGUS (monoclonal gammopathy of unknown significance) or paraproteinemia. MGUS includes about 2% of patients over the age of 50 described to have less than 3.5 gm/L of monoclonal Ig (Immunoglobulins), little or no proteinurea, (large amount of protein in the urine), fewer than 5% monoclonal marrow plasma cells, and no bone lesions, anemia, hypercalcemia, or renal dysfunction. In order for a diagnosis of Multiple Myeloma, it has to be distinguished from other disorders that are characterized as monoclonal gammopathies. This is the basic definition of MGUS as described in the American Association for Cancer Research, Holland Frei's, Cancer Medicine (Volume 7). Best of luck, Carm RN.

      over 5 years ago
    • Charlieb's Avatar

      Great response Carm. Other terms you may hear are: IGG; IGM; IGA. These are specific immunoglobulins which gives the indication of what type of blood disorder you have, IGG plays a key role for multiple myeloma. It would be best if you Google these.
      I was diagnosed with MGUS in 2007. My proteins started going up in 2011 and was then diagnosed with smoldering MM, then cancer. I have IGG Kappa MM, I forget the other types. You should make sure your doctor explains what they looking at. It is overwhelming at first.


      over 5 years ago

    Help the community by answering this question:

    Create an account to post your answer Already have an account? Sign in!

    By using WhatNext, you agree to our User Agreement, and Privacy Policy

    Read and answer more multiple myeloma questions.  Also, don't forget to check out our Multiple Myeloma page.