• What is monoclonal gammopathy?

    Asked by downbutnotout on Monday, April 15, 2013

    What is monoclonal gammopathy?

    1 Answer from the Community

    • carm's Avatar

      I answered thgis question on the site before so I just copy and pasted my answer here, I hope you don't mind. It goes by a few names other than monoclonal gammopathy. When something is deemed monoclonal, it means it gets its origin asexually from a single individual or cell. Monoclonal gammopathy is also known as MGUS (monoclonal gammopathy of unknown significance) or paraproteinemia. MGUS includes about 2% of patients over the age of 50 described to have less than 3.5 gm/L of monoclonal Ig (Immunoglobulins), little or no proteinurea, (large amount of protein in the urine), fewer than 5% monoclonal marrow plasma cells, and no bone lesions, anemia, hypercalcemia, or renal dysfunction. In order for a diagnosis of Multiple Myeloma, it has to be distinguished from other disorders that are characterized as monoclonal gammopathies. This is the basic definition of MGUS as described in the American Association for Cancer Research, Holland Frei's, Cancer Medicine (Volume 7). Best of luck, Carm RN.

      over 3 years ago

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