• When does rising PSA finally result in a diagnosis of castrate resistance?

    Asked by mgm48 on Tuesday, February 21, 2012

    When does rising PSA finally result in a diagnosis of castrate resistance?

    I'm seeing a 2 month straight rise in PSA and dr says wait til next month. Is ther any data on the time I have left?

    4 Answers from the Community

    4 answers
    • tspoon's Avatar

      They tell me it depends on the testosterone. We are in rhe same place. Psa rising, testosterone still at castration level but slowly coming up. He is stage 4.

      over 4 years ago
    • mgm48's Avatar

      Thanks Tspoon.

      I'm advanced - Metastasized to bone and some lymph nodes - lymph seems to have reduced but bones keep going PSA went from 117.9 to 22.7 November - December but January reading was 24.9 and February was 34.8 so I'm just wondering.....
      For the most part I'm tolerating the low testosterone ok and have very few symptoms. Living life as a positive experience. Working long hours of the CPA during Tax season.
      Best wishes.

      over 4 years ago
    • saltermd's Avatar

      I think tspoon is correct with the comments above. "Castrate-resistant" implies the cancer is progressing in spite of the absence of testosterone. Often physicians will confirm the patient is still "castrate" by rechecking testosterone levels. Once in awhile these tests will show there is substantial testosterone circulating in spite of Lupron, Eligard, etc. If the testosterone level is suppressed (as it should be in most cases) then a rising PSA indicates castrate resistant disease. This should be distinguished from "Androgen-independent" disease, where further hormone manipulations fail to affect the PSA. You may still respond to the addition of oral agents like bicalutamide (Casodex) or ketoconazole. Feel free to ask additional questions and good luck with tax season !

      over 4 years ago
    • mgm48's Avatar

      Saltermd - thanks, basically what I thought. Resumed Casodex in late December and PSA still rose in February - Can't wait to hear the news next week. HA HA
      Still having a great time reuniting with all my clients and remain pain free for the most part.
      Have noticed that the little things that always got sore (eg: back from snow shoveling) seem to nag on much longer these days. I assume it's from the lower testosterone.
      Sure is fun being in the middle of this.
      Just remember EVERYONE is RESPONSIBLE for being their own POSITIVE FORCE and all will be well.

      over 4 years ago

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