• Why are some post menopausals taking tamoxifen vs another ai?

    Asked by Lorie on Wednesday, June 7, 2017

    Why are some post menopausals taking tamoxifen vs another ai?

    Ive read which Ai is recommended for which age group but noticed here that some postmenopausal are taking tamoxifen with doctors consent to avoid bone deterioration and joint pain. A friend's daughter on an Ai is scheduling a hysterectomy because of pain. I didn't take it because it gave me headaches. My Onc did not suggest tamoxifen. I guess my question boils down to what are the downfalls of postmenopausals taking tamoxifen vs the others?
    Lorie

    7 Answers from the Community

    7 answers
    • janec0488's Avatar
      janec0488

      Lorie, I want to explore the same question. I took Tamoxifen for 5 yrs at 42 and then nothing for 11 years until my recurrence. Last spring I took Arimidex for 4 months, it did not stop my lymph node from continuing to get bigger and I had very bad nerve pain in the soles of my feet. I am now on exemestane. No nerve pain, some bone / arthritic pain in my fingers not bad. I am ok to going back on Tamoxifen even though I am post-metapausal.

      over 3 years ago
    • debco148's Avatar
      debco148

      There is a high risk of ovarian cancer with Tamoxifen, and the AI drugs are linked to Osteoperosis. I'll take that over O cancer. Both drugs block estrogren from feeding cancer cells. I read a study that compared both and suggest that use of Tamoxifen then AI drug is sometimes used in people who have cardiovascular risks already as AI drug can compound that. But, as far a reoccurance AI are better postmenopause, and Tamoxifen prior. Arimidex (Anastrozole) and Aromasin (Exemestane) are both equally effective AI drugs. I take Exemestane after it was confirmed I was postmenopause and have taken it for 4 years. Very few side effects and I am being monitored for Osteoperosis via yearly Dexa Scans. I found a lot of exercise and electrolytes such as potassium and magnesium cancel out leg pain, etc. You have to control diet and use adjunct therapies such as exercise, massage, accupuncture, Reiki etc. and you will be better than ever.. side effects disappear! Initially I was given a drug gabapentin for nerve pain after chemo and quit in a week.. horrible side effects from a drug that treats side effects!!! So I did my own thing and it works 100%!

      over 3 years ago
    • cak61's Avatar
      cak61

      I took Tamoxifin for a year and a half with no side effects until an ultrasound revealed a polyp in my uterus. Doctor and I decided on total hysterectomy. Was not cancer. Tamoxifin increases risk of uterine cancer (I've not heard increases risk of ovarian cancer).
      Was then switched to arimidex ( an aromatase inhibitor). The hot flashes we're horrible. And was then diagnosed with osteopenia.
      I was wanting to quit, so doctor suggested going back to tamoxifin, and I tolerated that much better.
      Also my last bone density scan showed improvement.
      Doctor said the AI's offer only a very slight improvement over tamoxifin.
      Both have side effects and risks.

      over 3 years ago
    • ChildOfGod4570's Avatar
      ChildOfGod4570

      My oncologist, knowing I have been several years without my cycle, didn't change my meds and kept me on Tamoxifen due to bone loss. She has now taken me off it for a month because of a thickening uterin wall, which test results show is fibroids that are benign. I have a check-up to see how I am doing after being off Tamoxifen for a month. Then she will see if Ineed to go back on it or if I need to take a different medication. HUGS and God bless.

      over 3 years ago
    • Sheryl88's Avatar
      Sheryl88

      I was put on Anastrozole because I had a pulmonary embolism after my mastectomy. Tamoxifen has a higher risk of blood clots. I have the leg pain that debco 148 mentioned ... I will try the magnesium and potassium. I have recently started to do more exercise, and it does help.

      over 3 years ago
    • debco148's Avatar
      debco148

      Sheryl88 you may also find relief in Epsom salt baths when and if the pain is bad. That allows magnesium into the muscle and calms the muscle spasms that often cause the pain. Just be careful on supplements not to take too much and let your doctor know. Exercise is the best for us with AI drugs because of the potential bone loss. Some aerobic exercise and weights may help strengthen the bones. I'm trying to learn more about this myself. Yoga helps a lot of my friends, I like Zumba for the type of intermittent training..aerobic, flow, squats, use of arms, etc. it provides. It makes me feel good and that is the key to it all..do what makes you feel good.

      over 3 years ago
    • Sheryl88's Avatar
      Sheryl88

      Thanks Debco 148. I have been using excuses far too long, it's time to get back moving!! Thanks for the advice! And motivation!!

      over 3 years ago

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