Have you discussed this with your oncologist are are you just assuming that the side effects will kick in immediately? In my case, I had chemo on Wednesdays and felt fine until Saturdays. If you schedule yours for Thursday or Friday, you may feel fine over the weekend and feel worst starting Monday or Tuesday.
I worked through chemo but I was able to customize my schedule to do some work from home and change my hours as needed. If I needed to take a day off I could make up for it by working longer hours the following week. My chemo was every 3 weeks, and I had significant side effect for a total of about 4-5 days each cycle. So with chemo every 3rd Wednesday, 2 of those days were a weekend and the other 2 were ones I could either work from home or make up on other days.