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    caensminger shared an experience

    Other Care (Home care): Home nurses come over three times per week for dressing changes, vitals, picc line maintenance, etc.

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    Side Effects (Constipation): I expected diarrhea. I ended up with mild constipation that also lead to a "blockage" in my GI tract. This blockage caused regurgitation. No nausea, sick or green feeling accompanied it. Also, no sweats or stomach acid came up. I just regurgitated food if there wasn't room for it to travel down. The feeling was upper GI pressure, severe discomfort, shallow breathing and panic. Once I looked at the toilet though, the food would come out, and I'd feel better within 30 minutes.

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    Side Effects (Rash): Horrific rash over entire body. I never want to go through that again. Prednisone and a break from treatment where necessary. Still dealing with the aftermath of all the skin that was damaged.

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    Drug or Chemo Therapy (Chemotherapy): Started 2 mg of Mekinist per day about the same time I also started the pembroluzimab. I experienced a HORRIFIC rash over 100% of my body. I had sores in my mouth, eyelids, my nostrils peeled along with red bumps, bursting capillaries, raised bumps and eventually a full body peel on 100% of me. Took two courses of Prednisone and discontinued treatments until it was "under control".

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    Drug or Chemo Therapy (Immunotherapy): Started Pembroluzimab/Keytruda along with Mekinist chemo at the same time. It's hard to determine which caused what side effect. My best guess is the diarrhea and regurgitation are caused by the pembroluzimab.

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    Decision Point (Out of approved treatments. Couldn't get into a trial. My oncologist didn't have any options and was befuddled. Went back to UCLA to exhaust all options. ): UCLA oncologist was able to clear a path towards two treatments, neither of which has much chance of helping at all. But we are trying.