• doggone's Avatar

    doggone asked a questionNon-Hodgkin Lymphoma (NHL)

    Why stop rituxan vs doing IgG replacement therapy

    • GilDBA's Avatar
      GilDBA

      While I only had rituxan during treatment, I too was constantly sick last year from January through June. They have been measuring my IGg levels which have been consistently falling even 22+ months after last dose.
      To avoid a repeat of last year, it was suggested that I see an immunologist who told me that rituxan has been known to suppress the IG levels, often permanently.
      This past week, I started IVGg.

      about 1 month ago
    • po18guy's Avatar
      po18guy

      This "may" be one of the long-term side effects of monoclonal antibodies such as Rituxan. I had only two infusions of a similar but reportedly more potent drug called Arzerra (Ofatumumab) in a clinical trial. Almost three years later, I am still B-Cell depleted. I am also sick with various viruses about 6 months out of the year.

      Here is a really old (1984) paper on elevated IgG and lymphoma. At that time, there was evidence that elevated IgG was both evidence of disease activity, as well as apparently contributing to thrombocytopenia - low platelets, which translates to bleeding problems. Every "cure", every treatment is a doubled-edged sword it seems.

      Certainly, there is newer research,but this may lean against IgG treatment.

      https://ashpublications.org/blood/article/63/4/944/10813/Platelet-associated-IgG-in-patients-with-lymphoma

      about 1 month ago
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    doggone asked a questionNon-Hodgkin Lymphoma (NHL)

    Rituxan and immune system and colds

    • po18guy's Avatar
      po18guy

      Sorry to hear about this. Rituxan depletes B lymphocytes, which are an integral prat of your immune system. How that plays out in a given individual depands on many factors. I received two infusions of Arzerra, the same class of drug as Rituxan (mnoclonal antibody) and two and one haf years later, I am still "B cell depleted" according to my blood work.

      I had a stem cell transplant in 2015 and have had two simultaneous viruses the past three years. What you might very well need to do is observe the precautions taken by transplant patients who have immune troubles. Information about those living with compromised immune systems can be found at www.bmtinfonet.org/

      7 months ago
    • GilDBA's Avatar
      GilDBA

      I have had 7 doses on rituxan the last almost 17 months ago. Since then I have had many more colds than I used to have and they seem to last longer. I had igg checked last year and they said that it was ok...

      7 months ago
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    doggone asked a questionNon-Hodgkin Lymphoma (NHL)

    Frequency of testing IgG level when on rituximab

    • GregP_WN's Avatar
      GregP_WN

      I see nobody has answered this for you, it must not be a common thing. One way of finding information on the site while waiting for others to see this and answer, is to look at the experiences tab at the top of any page. You can go to that page and type in rituximab and lgG level testing in the search box and you will get some experiences that have been listed in other people's journey.

      11 months ago
    • Schlegel's Avatar
      Schlegel

      When I was on maintenance Rituxan, I got the lab and treatment the same day. I don't know anything about IgG.

      11 months ago
    • icrazyhorse's Avatar
      icrazyhorse (Best Answer!)

      My Wife's CAR-T protocol requires an IVIG infusion when her IgG drops below 400. For the last 3 years she has dropped below 400 (and subsequently had an IVIG infusion) every 4 months. She gets an immunoglobulin blood test every month coincident with her port flush.

      11 months ago
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