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    happness asked a questionBreast Cancer

    Metaplastic carcinoma HER2 & ER +

    • carm's Avatar
      carm

      @happness,
      Hello, I am an oncology nurse and maybe I Can give you some insight. Metaplastic carcinoma (MpBC) with chondroid differentiation is a rare subtype of breast cancer. 
      It is usually a very high grade, and mostly ER-, PR-, and HER2-negative. So... MpBC with a positive reaction to ER, PR or HER2 are less common.
      Generally, most breast cancers cells arise from the glandular tissue of the breast however, metaplastic breast cancer is made up of other types of cells or other types mixed with glandular cells. Normal breast cells are called epithelial (glandular) cells but MpBC will also have mesenchymal cells (bone, skin or muscle) cells. That's the hallmark of MpBC. The general treatment is the same that most women with hormone positive cancers receive. First line is either TC (Taxotere and Cyclophosphamide) or TAC (Taxotere, Adriamycin and Cyclophosphamide) followed by maintenance of either Tamoxifen or an Aromitase Inhibitor plus maintenance Trastuzumab. I hope this helps and best of luck to you.

      2 days ago
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    Decision Point (Change of diagnosis after surgery and new pathology): Now I have to decide if the new treatment plan is something I want to go along with. It has lots of side effects and it is only a preventative measure.

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    Oh No (Change of diagnosis after surgery and new pathology): I was originally diagnosed with triple negative breast cancer and was told I had to have chemotherapy before surgery. They told me after chemo that if there was no sign the cancer had spread after the surgery that I probably wouldn't need further treatment after radiation, just observation. Now they are saying I need infusions every 3 weeks for a year and a pill a day for 5 years.

    2 Comments
    • beachbum5817's Avatar
      beachbum5817

      Wow, this certainly is confusing for you. Did they tell you why you need the added treatment? You need to have them tell you. The only drug that I know of that is taken every 3 weeks for a year is Herceptin. Are they now saying that you are HER2+? If you aren't happy with the answers, I would find another doctor to give you a second opinion. Let us know how you are doing. Take care.

      8 days ago
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      Bengal

      They don't always get it right in the early days of diagnosis. I was initially told I had a tiny, almost insignificant tumor. Lumpectomy followed by a short regimen of radiation and done. When I saw my oncologist after my surgery almost the first word out of her mouth was "chemo." I was shocked! She went on to explain that the tiny little tumor had turned out to be larger than expected, was HER2+ and a lengthy treatment including chemo/radiation/herceptin/anastrozole was her recommendation. Holy cow! I guess on this journey we have to learn to expect the unexpected.

      7 days ago
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    Question: Starting chemo