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    Wall_i_appreciate_kindness

    Do you have some friends who are like this, they always check up on you to be sure that you are OK and to see if you need anything, while others you never hear a peep out of? I try not to dwell on it, but c'mon!

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    • GregP_WN's Avatar
      GregP_WN

      Thanks for posting, I can appreciate those who stand by any cancer patient.

      9 days ago
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    Julesmom asked a questionBreast Cancer

    Are any of you taking Letrozole? This study finds a connection to chemobrain and Mood Swings

    • po18guy's Avatar
      po18guy

      Maybe, but then again, maybe not. Such effects often do not make the leap from primate to human. Same with many antineoplastic drugs. Many are abandoned as their effectiveness in vitro does not translate to in vivo testing. More study is certainly warranted, but with the threat imposed by relapsed breast cancer, some risks may be worth assuming. The good news is that BC looms large on the radar and considerable amounts of research into more potent and less toxic treatments is proceeding rapidly.

      28 days ago
    • ChicagoSandy's Avatar
      ChicagoSandy

      Any cognitive problems associated with the use of letrozole (or any aromatase inhibitor) likely stem from their effectively doing their job in reducing the amount of estrogen in the body. Estrogen deprivation accelerates the effects of aging (or results in a "rerun" of those of menopause), which include not just joint pain/osteoarthritis exacerbation, impaired metabolism/weight gain. impaired heat tolerance & body temperature regulation (hot flashes or night sweats), but "brain fog."

      Studies (retrospective & anecdotal--it's considered unethical to give cancer patients the placebos necessary for a valid double-blind prospective study) differ as to this effect in humans; but it's pretty well-settled that if it occurs, AI-induced cognitive impairment is milder and more fleeting than cytotoxic chemo-brain (because the latter actually kills tumor and rapidly-dividing healthy cells, whereas AI therapy selectively starves ER+ tumor cells).

      Retrospective studies of whether the effect is reversible after AI therapy ends need to be done--especially since more and more patients are staying on AIs longer than 5 years (most commonly, 7-10 yrs. and some even for life).

      28 days ago
    • Juls66's Avatar
      Juls66

      ChicagoSandy- thank you for your answer. I now understand why I wear Capri pants in winter here in Utah. I have been very warm since my chemo. This year I have started to need short sleeves but long pants☺

      24 days ago
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    Wall_behind_every_song_is_an_untold_story

    Every time I hear a particular song, I think of the day I was diagnosed because it was on the radio when I came out of the doctor's office. Now I call it my "cancer song". Do any of you have a song like this?

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