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    Leukemia_WN wrote on Beacezum's wall

    Welcome to WhatNext. Please let us know when you need information, help, inspiration, motivation or just a shoulder to lean on. There are lots of people here that have already been through almost everything you can imagine and they are more than happy to help. Post what you need to know on the questions page.

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    Yes it can, a year and all the treatments, side effects, procedures, and life added to it.

    • LiveWithCancer's Avatar

      You are so right!!!

      over 2 years ago
    • JaneA's Avatar

      Five years ago, I was in the midst of a battle for my life. Stage IV rectal cancer. I look back in wonderment at all of the chemo and radiation and surgery. But I am still here today and NED. I had an awesome medical team who put everything together. I just showed up and did the journey day by day.

      over 2 years ago
    • Coloman's Avatar

      Yes it sure can change. Life entirely.

      over 2 years ago
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    Leukemia_WN asked a questionLeukemia

    Step forward in leukemia treatment

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    Step forward in leukemia treatment
    by South Australian Health and Medical Research Institute

    An international clinical trial involving Adelaide researchers has demonstrated the safety and efficacy of a next-generation treatment for people with chronic myeloid leukemia (CML).

    The study's lead author, Professor Tim Hughes, says successful development and testing of the new kinase inhibitor called asciminib is the biggest breakthrough in CML treatment this century.

    The development of the original tyrosine kinase inhibitor (TKI) called imatinib in the 1990s changed CML from a death sentence to a disease that in many patients could be managed until they lived to a ripe old age," Professor Hughes said.

    "But while imatinib and subsequent TKIs have been very effective at improving survival, they frequently cause serious side-effects."

    TKIs that are currently approved for use are not well targeted, attacking leukemia cells but also damaging healthy cells. Professor Hughes, a Cancer Council SA Beat Cancer Professor, says asciminib selectively blocks the mutant kinase present in the leukemic cells.

    "This trial of 150 patients showed asciminib is highly effective, even in patients who'd failed to respond to several other TKIs," Professor Hughes said.

    "Equally as important, it's well tolerated by patients and appears to have significantly less long-term ill-effects compared to current treatments."

    The results of this clinical trial were published today in the esteemed New England Journal of Medicine.

    CML is a blood cancer that causes bone marrow to produce too many white blood cells. This excess of mutant white blood cells interferes with normal blood cell production. TKIs slow or stop this excess production of white blood cells.

    Over 4,000 Australians are living with CML currently however the increasingly high survival rate brought about by TKI treatment means the disease is estimated to be the most common form of leukemia by 2040.

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    Leukemia_WN posted an update

    What Causes Scarring of the Lungs?

    Scarring of lung tissue causes a variety of problems, from difficulty breathing to lack of adequate oxygen intake for optimal function of body organs. Understanding the causes of lung tissue damage helps you make wiser choices about your lifestyle habits. Damage to the bronchi, the two major airways to the lungs; the bronchoiles, the smaller branches of airways; or the alveoli, the small air sacs, may be affected by lifestyle, disease and environmental factors, which can lead to scarring of the lungs.

    Long term exposure to pollutants in the air may lead to lung damage and scarring. For example, metal dust shavings, asbestos or inhaling silica dust particles are environmental hazards of working in the construction industry. A pool cleaner who continually inhales chlorine or acid fumes may also experience some scarring of lung tissues. Farm workers exposed to chicken droppings or dust, moldy hay dust particles or grains grown in crops also face risks of lung damage, according to the Mayo Clinic.

    Radiation Therapy
    If you have been diagnosed and treated for lung cancer with radiation therapy, you may also suffer some lung damage caused by scarred tissues. The degree of damage is determined by the length and duration of radiation treatments and whether or not the person was also treated with chemotherapy drugs congruent with the radiation therapy. Some chemotherapy drugs also cause damage and scarring to the membranes lining and protecting the lungs, according to the Mayo Clinic.

    Pulmonary Fibrosis
    Idiopathic pulmonary fibrosis is caused by a gradual thickening of lung tissues, according to the Pulmonary Fibrosis Foundation. Fibrosis is a medical term for scarring, and idiopathic means there is no known cause for the condition. This thickening leads to large areas of scarring and prevents the affected lung tissues from properly receiving, exchanging or transferring vital oxygen to all parts of the body. Idiopathic pulmonary fibrosis is one of many types of interstitial lung disease processes, which may potentially lead to damage or scarring to the lungs.

    A great majority of lung scarring cases may be caused by pneumonia, according to the University of Maryland Medical Center. Pneumonia inflames lung tissues, causes damage and produces scarring in the interstitium, or fluids in the lungs that lubricate and protect the alveoli, or air sacs in the lungs, according to Medline Plus and the National Institutes of Health.