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    Penn45 asked a questionBreast Cancer

    TNBC recurrence and (heavily) androgen positive

    6 answers
    • fiddler's Avatar
      fiddler

      This is from a published scientific paper: The significance of androgen receptor (AR) expression in triple-negative breast cancer (TNBC) is unclear, and published studies so far have been inconclusive.
      https://www.ncbi.nlm.nih.gov/pubmed/24046116/

      about 2 years ago
    • fiddler's Avatar
      fiddler

      This is from a published scientific paper: The significance of androgen receptor (AR) expression in triple-negative breast cancer (TNBC) is unclear, and published studies so far have been inconclusive.
      https://www.ncbi.nlm.nih.gov/pubmed/24046116/

      about 2 years ago
    • fiddler's Avatar
      fiddler

      Sorry, here's the conclusion (note the word 'may'):
      The AR is expressed in normal breast tissue, and expression decreases with advancement to DCIS and invasive cancer. AR-positive TNBC was more common in older patients and had a higher propensity for LN metastases. AR-positive TNBC may represent a breast cancer subtype with unique features that may be amenable to treatment with alternative targeted therapies.

      about 2 years ago
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    Penn45 asked a questionBreast Cancer

    Triple negative recurrence?

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    Penn45 asked a questionBreast Cancer

    Mastectomy necessary after triple negative recurrence?

    • cswwhatnext's Avatar
      cswwhatnext

      I had a triple negative recurrence 10 months after my last radiation treatment. Prior to rads I had a lumpectomy and 4 rounds of A/C and 12 of Taxol. After the recurrence they recommended a double mastectomy and platinum based chemo. I did the chemo then had the mastectomies in April of this year. My recurrence was just centimeters away from my original tumor in the same breast. It had not spread anywhere else.

      about 3 years ago
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